منابع مشابه
Lack of the antioxidant glutathione peroxidase-1 (GPx1) exacerbates retinopathy of prematurity in mice.
PURPOSE Glutathione peroxidase-1 (GPx1) is highly expressed during normal retinal maturation; however, its role in retinopathy of prematurity (ROP) is not fully understood. We postulated that GPx1 plays an important role in protecting the premature retina from oxidative injury in a mouse model of ROP. METHODS ROP was induced in wild-type (WT) and GPx1 knockout (KO) mice by exposing neonatal m...
متن کاملAssociation between glutathione peroxidase-1 (GPX1) Rs1050450 polymorphisms and cancer risk
Glutathione peroxidase (GPX), one of the antioxidant enzymes, exerts a vital role in reducing oxidative damage. GPX1 Pro198Leu (rs1050450) polymorphism has been reported in the development of several cancers, while the results were inconsistent. We thus conducted this meta-analysis to identify the association between GPX1 (rs1050450) polymorphism and cancer risk. 52 eligible publications with 6...
متن کاملLow glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from g-irradiation damage
Esworthy, R. Steven, Jeffrey R. Mann, Mindy Sam, and Fong-Fong Chu. Low glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from g-irradiation damage. Am J Physiol Gastrointest Liver Physiol 279: G426–G436, 2000.—Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after $10 Gy g-irradiatio...
متن کاملGenetic association analysis of the glutathione peroxidase (GPX1) gene polymorphism (Pro197Leu) with tardive dyskinesia.
A possible involvement of oxidative stress in the pathophysiology of tardive dyskinesia (TD) has previously been proposed (reviewed in [Andreassen, O.A., Jorgensen, H.A., 2000. Neurotoxicity associated with neuroleptic-induced oral dyskinesias in rats. Implications for tardive dyskinesia? Progress in Neurobiology 61, 525-541.]). Long-term administration of neuroleptics alters dopaminergic turno...
متن کاملLow glutathione peroxidase activity in Gpx1 knockout mice protects jejunum crypts from gamma-irradiation damage.
Gpx1 knockout (KO) mice had a higher number of regenerating crypts in the jejunum than did Gpx2-KO or wild-type mice analyzed 4 days after > or =10 Gy gamma-irradiation. Without gamma-irradiation, glutathione peroxidase (GPX) activity in the jejunal and ileal epithelium of Gpx1-KO mice was <10 and approximately 35%, respectively, of that of the wild-type mice. Four days after exposure to 11 Gy,...
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ژورنال
عنوان ژورنال: Atlas of Genetics and Cytogenetics in Oncology and Haematology
سال: 2014
ISSN: 1768-3262
DOI: 10.4267/2042/53966